Polidoro de Rienzo da Lanciano (Lanciano, 1515–1565) was an Italian painter. Relatively little is known of his life. He was born in Lanciano, a town that is a few miles inland from Ortona, a port on the Adriatic Sea. This is in the Abruzzi region of Italy, lying southeast of Pescara. His grandfather, Alessandro Rienzo, was a ceramic painter in Lanciano. Based on Venetian documents Polydoro's birthdate is taken to be 1515. At an early age he apparently showed great artistic talent.