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Guglielmo de Sanctis (March 8, 1829 – 1911) was an Italian painter. He was a pupil of Tommaso Minardi at the Accademia di San Luca in Rome, and wrote a biography about his teacher. He also spent some time in the studio of Cesare Marianecci in Florence. Early in his career, he painted religious and historic themes, in a style highly influenced by his master's Purismo movement, an Italianate incarnation of the Nazarene movement.